NCT04100564

LITES Task Order 0005 Prehospital Airway Control Trial (PACT)

Prehospital Airway Control Trial : A Randomized Controlled Trial of Prehospital Airway Management Strategy for Trauma Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,010 (actual)
• Sponsor: Jason Sperry · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outcomes to include survival to hospital discharge, expected clinical adverse events, airway management performance, ICU length of stay, ventilator days, incidence of ARDS, and incidence of ventilator associated pneumonia. Subjects will be enrolled across approximately 17 prehospital agencies at select LITES Network sites and will enroll a total of 2,009 subjects.

Conditions

• Trauma Injury
• Airway Control

Interventions

Type	Name	Description
DEVICE	Supraglottic airway device	Initial advanced airway management with a supraglottic device
OTHER	Standard airway management	Initial advanced airway management with standard care method

Timeline

• Start date: 2021-04-01
• Primary completion: 2026-03-07
• Completion: 2026-04-07
• First posted: 2019-09-24
• Last updated: 2026-04-14

Locations

14 sites across 1 country: United States

Regulatory

• FDA-regulated device study