NCT04095949

Absorption, Metabolism and Excretion of Artichoke Polyphenols in Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

A number of studies have reported the presence of polyphenolic compounds in artichokes, being the most abundant the caffeoylquinic acids (CQAs), which are esters between quinic acid and the hydroxycinnamate caffeic acid. The fate of artichoke polyphenols in humans after ingestion is currently unknown. The acute study will provide novel information on the bioavailability and metabolism of artichoke polyphenols, which will give important insights to understand the potential health benefits of artichoke consumption. Health men and women participants (n=8) aged between 18 to 40 years old will be recruited. Participants will consume a normal ration of artichokes once. The participants will provide the investigators with urine and blood samples for polyphenol analysis at baseline and at different time points until 24 hours.

Conditions

• Healthy Men and Women

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Artichokes	Approximately 200 g of cooked artichokes

Timeline

• Start date: 2019-07-17
• Primary completion: 2019-07-30
• Completion: 2019-07-30
• First posted: 2019-09-19
• Last updated: 2019-10-14

Locations

1 site across 1 country: United Kingdom