NCT04095780

The Effectiveness of Oral Health Promotion on Pneumonia Complicating Stroke

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 166 (actual)
• Sponsor: Anhui Medical University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

To investigate the evidence for the integration of oral health promotion as part of interdisciplinary stroke rehabilitation.

Detailed description

Pneumonia complicating stroke is very difficult to manage and has a very poor prognosis, leading to a significantly higher risk of death. Oral opportunistic pathogens have been reported to be associated with the incidence of pneumonia among non-stroke immunocompromised subjects. Preliminary studies found that patients with stroke had higher carriage rates of oral opportunistic pathogens than healthy subjects. Therefore, investigators hypothesize that pneumonia complicating stroke is associated with oral opportunistic pathogens, and oral health promotion interventions may reduce the incidence of pneumonia complicating stroke via its effects on the species and relative abundance of oral opportunistic pathogens. In order to prove this, investigators need to (1) firstly conduct a randomized controlled trial to confirm whether oral health promotion is able to reduce the levels of plaque, and the incidence of pneumonia complicating stroke at clinical level; (2) secondly employ metagenomics analysis to compare oral rinse samples and respiratory samples, and to identify pneumonia-associated "oral opportunistic pathogens group"; (3) finally elucidate how oral health promotion influences the species and relative abundance of oral opportunistic pathogens. This proposed study will provide evidence for the integration of oral health promotion as part of interdisciplinary stroke rehabilitation.

Conditions

• Stroke
• Pneumonia
• Oral Hygiene

Interventions

Type	Name	Description
OTHER	Advanced oral hygiene care programme	1. Brush teeth with standardized power tooth brush twice a day. 2. Rinse mouth with chlorhexidine twice a day. 3. Oral hygiene education
OTHER	Oral hygiene instruction	Oral hygiene education

Timeline

• Start date: 2018-11-01
• Primary completion: 2021-06-01
• Completion: 2021-06-01
• First posted: 2019-09-19
• Last updated: 2022-07-21

Locations

1 site across 1 country: China