Trials / Withdrawn
WithdrawnNCT04095546
Epigenetic Changes in Psychotherapy of Adolescents With Borderline Personality Pathology
- Status
- Withdrawn
- Phase
- —
- Study type
- Observational
- Enrollment
- 0 (actual)
- Sponsor
- University Hospital, Basel, Switzerland · Academic / Other
- Sex
- All
- Age
- 14 Years – 18 Years
- Healthy volunteers
- Not accepted
Summary
The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1. Change in methylation of these genes could be a biomolecular mechanism of psychotherapy induced changes. This study project aims at providing evidence for a biological mechanism of personality disorder interventions in adolescence by investigating the link between epigenetic changes as an effect of psychotherapy. It investigates the correlation between changes in the methylation of the FKBP5 gene and psychotherapy induced changes in symptoms and functioning.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | routine psychotherapy for Borderline Personality Disorder (BPD) | Routine psychotherapy as treatment for patients with Borderline Personality Disorder |
Timeline
- Start date
- 2022-04-01
- Primary completion
- 2024-02-01
- Completion
- 2024-12-01
- First posted
- 2019-09-19
- Last updated
- 2022-09-13
Source: ClinicalTrials.gov record NCT04095546. Inclusion in this directory is not an endorsement.