NCT04094038

The Effect of Intradialytic Parenteral Nutrition on Nutritional Status and Quality of Life in Hemodialysis Patients

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 166 (estimated)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Protein-energy wasting (PEW), a hypercatabolic state characterized by loss of muscle mass and fuel reserves, is highly prevalent in hemodialysis patients. Nutritional status and body composition are closely linked to morbidity, mortality and quality of life. Lean tissue mass (LTM) appears to be the best read-out for the association between nutritional status and outcomes. Intradialytic parenteral nutrition (IDPN) is occasionally used with the aim to reduce loss of LTM, but its efficacy has not been established. The goal of this study is to study the effect of IDPN on changes in LTM in hemodialysis patients.

Conditions

• End Stage Renal Disease
• Malnutrition
• Sarcopenia
• Hemodialysis Complication

Interventions

Type	Name	Description
DRUG	Olimel N12	A mixture of glucose, lipids, amino acids.
DRUG	Glucose IV	Glucose 5%

Timeline

• Start date: 2019-09-16
• Primary completion: 2024-04-02
• Completion: 2026-07-01
• First posted: 2019-09-18
• Last updated: 2026-02-12

Locations

2 sites across 1 country: Netherlands