NCT04088617

The Effects of Exogenous Ketones on Glucose Tolerance

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to a high carbohydrate mixed meal in young healthy individuals.

Conditions

• Dietary Supplement: Ketone Supplement
• Dietary Supplement: Placebo

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone monoester	Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior a 2-hour high carbohydrate mixed meal tolerance test.
DIETARY_SUPPLEMENT	Placebo	Acute ingestion of a taste-matched placebo prior a 2-hour high carbohydrate mixed meal tolerance test.

Timeline

• Start date: 2019-08-01
• Primary completion: 2019-10-30
• Completion: 2020-01-05
• First posted: 2019-09-13
• Last updated: 2020-03-24

Locations

1 site across 1 country: Canada