NCT04088344

Effect of a Carbohydrate-rich Diet in Healthy Subjects

The Relative Contribution of Dietary Lipids vs. of Fatty Acids to Non-adipose Tissues and the Effect of a Carbohydrate-rich Diet in Healthy Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The present research protocol will analyze whether a short-term modification (one week) of dietary habits would have an impact on the postprandial metabolism of dietary fatty acids and on their uptake by non-adipose tissues, in healthy subjects. Each subject will participate in two protocols randomly determined and separated by a period of one month: a 7-day isocaloric diet (Protocol A) and a 7-day carbohydrate-rich diet containing +50% of the subject's energy needs. (Protocol B). At the end of each diet, the subject will go through a postprandial metabolic study of 8 hours where different parameters will be measured thanks to PET imaging and perfusions of stables isotopes.

Conditions

• Lipid Metabolism Disorder

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	isocaloric diet	a 7-day isocaloric diet
DIETARY_SUPPLEMENT	Hypercaloric diet	A 7-day hypercaloric diet supplemented with carbohydrate-rich food (+ 50% of the subject's energy needs).
OTHER	Liquid meal
RADIATION	PET imaging
OTHER	perfusions of stable tracers
DEVICE	Indirect calorimetry

Timeline

• Start date: 2013-04-10
• Primary completion: 2019-03-20
• Completion: 2019-07-02
• First posted: 2019-09-12
• Last updated: 2019-09-12

Locations

1 site across 1 country: Canada