NCT04088305

Vancomycin Dosage Strategy Based on a Trough Concentration Model

Clinical Evaluation of a Vancomycin Dosage Strategy Based on a Serum Trough Concentration Model in Elderly Patients With Severe Pneumonia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Study design: Allocation: Randomized Endpoint classification: Efficacy study Masking: Open label Primary purpose: Treatment Primary endpoint: Incidence of reaching the target serum trough concentration Secondary endpoint: Clinical efficiency, Antibiotic use, acute kidney injury.

Detailed description

This is a prospective randomized control trial. There are two groups, study group and control group. Patients of study group accepted vancomycin strategies decided by a serum trough concentration model, and patients of control group accepted vancomycin dosage decided by attending physician. The primary endpoint is the incidence of reaching the target serum trough concentration, the secondary endpoint are clinical efficiency, antibiotic use and side effects such as acute kidney injury, etc.

Conditions

• Pneumonia, Staphylococcal

Interventions

Type	Name	Description
DRUG	Individualized therapy	Dosage of Vancomycin decided by a serum trough concentration model, instead of decided by attending physician

Timeline

• Start date: 2019-10-01
• Primary completion: 2022-05-31
• Completion: 2022-06-30
• First posted: 2019-09-12
• Last updated: 2022-08-31

Locations

1 site across 1 country: China