NCT04086849

Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic Markers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 450 (actual)
• Sponsor: Sunnybrook Health Sciences Centre · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Here, the investigators will develop a clinicopathomic assay from biomarkers obtained from digital pathologies of resected whole-mount oral cavity and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) specimens with the goal of administering personalized novel image-guided therapies immediately after primary surgical management in OCSCC and OPSCC patients. The primary aim is to determine the association between clinicopathomic biomarkers and LRR. The secondary aim is to develop a clinicopathomic risk score (assay) such that a decision-support tool can be used by physicians for measuring the benefit of additional therapies (i.e. conventional chemotherapy +/- radiation or administering dose-escalated chemoradiation) in the adjuvant setting to reduce LRR rates.

Detailed description

The proposed study is significant for developing personalized treatments. The proposed research will yield high rewards to patients by providing additional information to clinicians for better prognostication and potentially adapting adjuvant treatments to improve the survival of patients with OCSCC or OPSCC.

Conditions

• Head and Neck Neoplasm
• Squamous Cell Carcinoma of Head and Neck

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Radiomic, pathomic, and clinical markers	This is a non-interventional study.

Timeline

• Start date: 2019-07-30
• Primary completion: 2021-03-26
• Completion: 2021-04-05
• First posted: 2019-09-12
• Last updated: 2023-04-11

Locations

1 site across 1 country: Canada