NCT04086589

Restoring Molecular Circadian Rhythm

Exploratory Pilot Study to Discover Genes That Restore the Molecular Circadian Rhythm

• Status: Suspended
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 20 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).

Conditions

• Healthy Young
• Healthy Elderly

Interventions

Type	Name	Description
OTHER	Observational study without intervention	Observational study without intervention

Timeline

• Start date: 2019-08-19
• Primary completion: 2028-01-01
• Completion: 2028-11-01
• First posted: 2019-09-11
• Last updated: 2026-01-23

Locations

1 site across 1 country: United States