NCT04086108

Relative Oral Bioavailability of GABA From Tomatoes

Plasmakinetics of GABA From Tomatoes as Compared to GABA From a Supplement, After a Single Oral Administration in Healthy Young Men

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Wageningen University · Academic / Other
• Sex: Male
• Age: 18 Years – 28 Years
• Healthy volunteers: Accepted

Summary

In this four-way crossover study, a plasmakinetic profile of GABA from tomatoes as compared to a gamma-aminobutyric acid (GABA) supplement in healthy young men will be established. In addition, a plasmakinetic profiles of glutamate from a supplement and from tomatoes as well as the effects of glutamate from tomatoes and a supplement on the GABA plasma levels will be determined. This study will therefore provide information about the effect of a food matrix on GABA plasmakinetics.

Conditions

• GABA Plasmakinetics

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Tomato	A maximum of 1 kilo pureed tomatoes, containing 1 gram of GABA.
DIETARY_SUPPLEMENT	GABA supplement	1 gram of GABA dissolved in water.
DIETARY_SUPPLEMENT	Glutamate supplement	A maximum of 8 grams glutamate, adjusted to amount of glutamate given in the tomato arm. Dissolved in water.

Timeline

• Start date: 2019-11-04
• Primary completion: 2019-12-05
• Completion: 2019-12-05
• First posted: 2019-09-11
• Last updated: 2020-01-21

Locations

1 site across 1 country: Netherlands