NCT04084561

Risk Communication in African American Smokers

Nicotine Dependence and Lung Cancer Genetics in African Americans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 166 (actual)
• Sponsor: Temple University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry. Participants will be given hypothetical personalized genetic risk results and ask to think about how they might respond to such information if they actually received such results.

Detailed description

The study aims to understand the effects of learning about one's genetic risk for lung cancer that is specific to their ancestry. Smokers will be randomized to receive hypothetical information about their genetic status and consider how they think they would respond if such results were actually presented to them. They will be randomly assigned to receive one of four sets of hypothetical genetic results: 1) High risk of lung cancer and high genetic African ancestry, 2) High risk of lung cancer and low genetic African ancestry, 3) Low risk of lung cancer and high genetic African ancestry, or 4) Low risk of lung cancer and low genetic African ancestry. After being given this hypothetical information, participants will complete brief questionnaires assessing perceived risk of lung cancer, worry about cancer, psychological distress, and motivation to quit smoking.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
BEHAVIORAL	HRHA	participants will be asked to consider a hypothetical scenario in which genetic test results reveal that: 1) they carry genotypes that place African American smokers at a particularly high (\~50%-80%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly high concordance with African heritage (\~90%).
BEHAVIORAL	LRLA	participants will be asked to consider a scenario in which genetic test results reveal that: 1) they are at normal (\~7%-10%) risk for the development of lung cancer, and 2) their genetic profile reflects a particularly low concordance with African heritage (\~10%).
BEHAVIORAL	HRLA	participants will receive "High Risk, Low Ancestry (HRLA)" hypothetical
BEHAVIORAL	LRHA	participants will receive "Low Risk, High Ancestry (HRLA)" hypothetical

Timeline

• Start date: 2018-09-01
• Primary completion: 2022-04-01
• Completion: 2022-04-01
• First posted: 2019-09-10
• Last updated: 2023-12-18
• Results posted: 2023-12-18

Locations

2 sites across 1 country: United States