NCT04079725

Iris Tissue in Primary Congenital Glaucoma

Histopathological Examination of Iris Tissue in Primary Congenital Glaucoma

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 7 Days – 1 Year
• Healthy volunteers: Not accepted

Summary

To present the histopathological features of the iris tissue in primary congenital glaucoma which may play a role in pathogenesis

Detailed description

Primary congenital glaucoma etiology still remains obscure . originally barkan , and later Worst , proposed that a membrane covered the anterior chamber angle and blocked aqueous outflow , but the presence of that membrane has not been established histopathologically to date . Now most authors believe that the site of obstruction is the trabecular meshwork rather than an overlying membrane . Maldevelopment of the anterior segment is present in all forms of congenital glaucoma . this maldevelopment may involve the trabecular meshwork alone or the trabecular meshwork in combination with the iris or cornea or both. In approcimately 50% of patients , isolated trabeculodysgensis is the only developmental ocular anomaly found .This is the classic defect found in primary congenital glaucoma .These eyes have no developmental anomalies of iris or cornea present except abnormal insertion of the iris into the angle

Conditions

• Primary Congenital Glaucoma

Interventions

Type	Name	Description
PROCEDURE	Combined trabeculotomy-trabeculectomy with mitomycin c	Combined trabeculotomy-trabeculectomy with mitomycin C Will be done in all cases then histopathological examination of iris tissue to detect the nature of the disease

Timeline

• Start date: 2020-12-01
• Primary completion: 2021-09-01
• Completion: 2022-03-01
• First posted: 2019-09-06
• Last updated: 2020-10-22