NCT04078776

Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 12 (actual)
• Sponsor: Loughborough University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese. Blood and white adipose tissue samples will be collected in the fasted state to assess inflammatory status. There is evidence to suggest that markers of inflammation in the blood and white adipose tissue increase with increasing levels of obesity. However, the white adipose tissue total protein content and phosphorylation of proteins involved in inflammatory pathways has not previously been compared between lean and obese individuals. The investigators hypothesise that obese individuals will have increased levels of inflammation in the blood and white adipose tissue, compared to their lean counterparts.

Conditions

• Inflammation
• Obesity
• Inflammatory Response
• Cardiovascular Risk Factor

Interventions

Type	Name	Description
OTHER	No intervention	There is no intervention in this study

Timeline

• Start date: 2019-10-25
• Primary completion: 2020-08-01
• Completion: 2020-08-01
• First posted: 2019-09-06
• Last updated: 2022-05-17

Locations

1 site across 1 country: United Kingdom