NCT04078659

Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

Controlled Hypotension During Endoscopic Sinus Surgery: A Comparison of Propofol and Magnesium Sulfate

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose. Propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property. Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking N-type calcium channel at the nerve ending beside acting as a vasodilator. The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium Sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

Detailed description

The aim of the work to compare the efficacy of propofol and magnesium sulfate to control blood pressure during endoscopic sinus surgery and the resultant effects on the quality of the surgical field including bleeding and visibility.

Conditions

• Endoscopic Sinus Surgery

Interventions

Type	Name	Description
DRUG	Propofol infusion	Following induction of anaesthesia, propofol infusion will be started 75 mcg/kg/min for the first 10-15 minutes, then a maintenance infusion of propofol (50 mcg/kg /min)
DRUG	Magnesium Sulfate infusion	Before induction of anaesthesia, Magnesium Sulfate infusion will be started at 40 mg/kg in 100 ml saline over 10 minutes as the loading dose then Magnesium sulfate infusion 10-15 mg/kg/hr started immediately after induction of anaesthesia
DRUG	Lidocaine	Patients will receive iv lidocaine 1.5 mg/kg before induction of anaesthesia
DRUG	Fentanyl	Patients will receive fentanyl 1-2 mcg/kg before induction of anaesthesia
DRUG	Propofol	Patients will receive propofol in a dose of 1-2 mg /kg
DRUG	Atracurium	Patients will receive 0.6 mg /kg iv atracurium over 60 sec, to facilitate tracheal intubation
PROCEDURE	Mechanical Ventilation	Patients lungs will be ventilated using the volume controlled mechanically ventilated with 40% oxygen in the air with positive end-expiratory pressure (PEEP) of 5 cmH2O, tidal volume 500 ml and Respiratory Rate of 12 per minute

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-01-01
• Completion: 2020-02-01
• First posted: 2019-09-06
• Last updated: 2019-09-06

Locations

1 site across 1 country: Egypt