Trials / Withdrawn
WithdrawnNCT04078581
Profiling Fecal Samples for Selection of Donors of Feces
Profiling Fecal Samples to Optimize Selection of Stool Donors for Fecal Microbiota Transplantation
- Status
- Withdrawn
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 0 (actual)
- Sponsor
- Assistance Publique - Hôpitaux de Paris · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Fecal microbiota transplantation (FMT) represents a promising therapeutic in numerous clinical situations associated with dysbiosis. Today, this procedure is recommended in patients with recurrent Clostridioides difficile infections but beneficial effects of FMT have also been described in other diseases associated with intestinal dysbiosis …. A donor effect which could be related to the inter-individual variability of microbiota and microbiome leading to specific metabolic capacities may influence the efficacy of the procedure.
Detailed description
Fecal microbiota transplantation (FMT) represents a promising therapeutic in numerous clinical situations associated with dysbiosis. Today, this procedure is recommended in patients with recurrent Clostridioides difficile infections but beneficial effects of FMT have also been described in other diseases associated with intestinal dysbiosis …. A donor effect which could be related to the inter-individual variability of microbiota and microbiome leading to specific metabolic capacities may influence the efficacy of the procedure. The aim of our study is to measure fecal biochemical, microbial and immunological parameters that are known to influence gut homeostasis in a group of 40 healthy donors to establish a referential profile of human stools to optimize donor profiling, beyond the infectious parameters, to increase the success rate of FMT.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Questionnaire and fecal sample collection | Questionnaire and fecal sample collection in order to select donors for FMT. |
Timeline
- Start date
- 2020-03-01
- Primary completion
- 2021-06-01
- Completion
- 2021-06-01
- First posted
- 2019-09-06
- Last updated
- 2023-07-03
Source: ClinicalTrials.gov record NCT04078581. Inclusion in this directory is not an endorsement.