NCT04077125

Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy

Minimal Hepatic Encephalopathy is Associated With Increased Cerebral Vascular Resistance. a Transcranial Doppler Ultrasound Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact. Thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected patients. This study was aimed to investigate cerebral blood flow, systemic hemodynamics as well as endothelial function of cirrhotic patients with MHE, and to verify their change after treatment with rifaximin.

Conditions

• Minimal Hepatic Encephalopathy

Interventions

Type	Name	Description
DRUG	Rifaximin	to investigate changes in cerebral, splanchnic hemodynamics and endothelial function in cirrhotic patients with MHE after 15 days of rifaximin therapy (1200 mg/d)

Timeline

• Start date: 2018-01-18
• Primary completion: 2018-12-31
• Completion: 2019-03-01
• First posted: 2019-09-04
• Last updated: 2019-09-04

Locations

1 site across 1 country: Italy