Trials / Unknown
UnknownNCT04076124
Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain Stimulation
Different Forms of Prefrontal Transcranial Stimulation and Brain-derived Neurotrophic Factor in the Prediction of Antidepressant Efficacy of Brain Stimulation
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- Sponsor
- Taipei Veterans General Hospital, Taiwan · Other Government
- Sex
- All
- Age
- 21 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
This study evaluates an association between brain-derived neurotrophic factor(BDNF) polymorphisms and the antidepressant efficacy of transcranial magnetic stimulation device in patients with treatment-resistant depression. In a double-blind design, All patients are randomized to three groups, i.e.repetitive transcranial magnetic stimulation treatment, intermittent theta-burst stimulation treatment or sham treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Active rTMS-DLPFC | Participants in the rTMS active stimulation group will receive 4-week 10 Hz 120% of RMT to left DLPFC. Left side DLPFC will be targeted by MRI-neuronavigation system. Stimulation will be delivered to the L-DLPFC using a Magstim stimulator. |
| DEVICE | Active iTBS-DLPFC | Participants in the intermittent TBS(iTBS) active stimulation group will receive 4-week three-pulse 50-Hz bursts administered every 200 milliseconds (at 5 Hz) at an intensity of 80% active motor threshold (MT) to left DLPFC. Left side DLPFC will be targeted by MRI-neuronavigation system. Stimulation will be delivered to the L-DLPFC using a Magstim stimulator. |
| DEVICE | Sham TBS-DLPFC or Sham rTMS-DLPFC | Half of the patients in the sham group received 4-week the same iTBS parameter stimulation (sham-iTBS), and the other half received the same rTMS parameter stimulation using a sham coil (sham-rTMS), which also improved the blinding process. |
Timeline
- Start date
- 2019-07-24
- Primary completion
- 2021-09-30
- Completion
- 2021-12-31
- First posted
- 2019-09-03
- Last updated
- 2019-09-03
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT04076124. Inclusion in this directory is not an endorsement.