NCT04073719

Apple Cider Vinegar for the Prevention of Urinary Lithiasis (APUL)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: United States Naval Medical Center, San Diego · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess whether certain beverages can increase urinary citrate levels in healthy individuals with no history of kidney disease.

Detailed description

Higher urinary citrate levels have been shown to decrease one's risk of developing kidney stones. The study will compare apple cider vinegar, coconut water, diet citric soda and lemonade and determine which is superior at raising citrate levels. Research participants will consume two of the four drinks, each for 7 day periods, according to a prescribed regimen. Throughout the course of the study, participants will periodically provide blood draws for metabolic panels, as well as 24-hour urine samples to measure citrate levels. There will be 12 study arms, accounting for the permutations of two drinks for each patients out of four possibilities. 3 participants per arm is the goal, for a total of 36, but the recruitment aim is 50 participants, to account for dropout and noncompliance.

Conditions

• Kidney Stones, Urolithiasis, Hypocitraturia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Apple Cider Vinegar	Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
DIETARY_SUPPLEMENT	Other Beverage	To what degree do other high citrate beverages impact urinary citrate output.

Timeline

• Start date: 2019-09-01
• Primary completion: 2021-05-31
• Completion: 2022-05-31
• First posted: 2019-08-29
• Last updated: 2019-08-30