Trials / Completed
CompletedNCT04072913
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
Involvement of Matrix Metalloproteinases and Association With the Expression of Human Papillomavirus in Dysplasias and Cancers of the Cervix
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 216 (actual)
- Sponsor
- University Hospital, Bordeaux · Academic / Other
- Sex
- Female
- Age
- 20 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Detailed description
Cervical cancer is the second most common cancer among European women under 45 years old. It is secondary to cervical dysplasia induced by persistent human papillomavirus infection. The involvement of matrix metalloproteinases in carcinogenesis of the cervix is real, but their expressions vary according to the published series. An association between the expression of MMPs and that of the human papillomavirus deserves to be explored, as this can have a prognostic influence in the case of gradual expression demonstrated in the development of (pre) cancerous lesions of the cervix. This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Vaginal samples (biopsies + vaginal smear) | Two types of samples are envisaged: tissue (large biopsies, coin of conization or hysterectomy) to affirm the diagnosis and detect the matrix metalloproteinases and their tissue inhibitors by immunohistochemistry; cell sample (monolayer smear type) to evaluate the expression of oncogenic Human papillomavirus. |
Timeline
- Start date
- 2007-10-10
- Primary completion
- 2011-01-31
- Completion
- 2011-01-31
- First posted
- 2019-08-28
- Last updated
- 2019-08-28
Source: ClinicalTrials.gov record NCT04072913. Inclusion in this directory is not an endorsement.