NCT04070937

Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Jessa Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well. The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.

Conditions

• Hearing Loss, Sensorineural
• Bilateral Vestibular Deficiency
• DFNA9
• Radiology

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	vestibular test 1	videonystagmography
DIAGNOSTIC_TEST	vestibular test 2	video head impulse test
DIAGNOSTIC_TEST	vestibular evoked myogenic potentials	vestibular evoked myogenic potentials to measure the function of otolith organs
DIAGNOSTIC_TEST	audiometry	tonal liminar audiometric thresholds
DIAGNOSTIC_TEST	CT and MR imaging of temporal bone	Ct and MR imaging of temporal bone
GENETIC	p.P51S mutation	analysis of presence of p.P51S mutation in COCH

Timeline

• Start date: 2019-09-01
• Primary completion: 2026-10-30
• Completion: 2026-10-30
• First posted: 2019-08-28
• Last updated: 2021-08-25

Locations

1 site across 1 country: Belgium