NCT04070690

The Influences of Dialysate Bicarbonate Concentrations on Hemodialysis Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Camillians Saint Mary's Hospital Luodong · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Background: Patients with decreased kidney function are in the positive acid balance due to insufficient renal acid excretion. To correct the varying degrees of metabolic acidosis in these HD patients, a high concentration of HCO3 in the dialysate is routinely used. During every 3-to-4 hours of HD treatment, a massive surge of HCO3 would enter the circulation and typically overcorrects predialysis acidosis to alkalosis and alkalemia. The sharp acid-base shift can cause some adverse consequences. The investigators believe that the rapid correction (or overcorrection) from the pre-dialysis metabolic acidosis to post-dialysis metabolic alkalosis during the 3-to-4 hours HD treatment would relate to adverse effects on HD patients. Thus the investigators conduct this study to prove the hypothesis that "prevention of post-dialysis alkalosis by using lower dialysate HCO3 concentration might cause less adverse outcomes in ESRD patients on HD." Study design: Prospective cross-over case-control study. Study population: A total of 60 patients who receive regular hemodialysis (three times per week) for more than 6 months in the regional teaching hospital.

Conditions

• End Stage Renal Disease on Dialysis

Interventions

Type	Name	Description
PROCEDURE	Concentration of dialysate bicarbonate	Adjust the dialysate bicarbonate concentration

Timeline

• Start date: 2019-08-01
• Primary completion: 2020-01-01
• Completion: 2020-02-01
• First posted: 2019-08-28
• Last updated: 2019-08-28

Locations

1 site across 1 country: Taiwan