NCT04067440

Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

Characterization and Comparison of the Human Microbiome in Peritoneum, Jejunum, Rectum and Stool

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Universität des Saarlandes · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.

Detailed description

Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum. The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall. Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.

Conditions

• Obesity
• Diabetes Mellitus
• Fatty Liver, Nonalcoholic
• Leaky Gut Syndrome
• Chronic Pancreatitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Microbial Swab	Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool

Timeline

• Start date: 2019-10-01
• Primary completion: 2023-07-30
• Completion: 2024-07-30
• First posted: 2019-08-26
• Last updated: 2025-05-29

Locations

1 site across 1 country: Germany