NCT04065945

Epigenetic Safety of Assisted Reproductive Technology

Epigenetic Safety of Various Protocols in Assisted Reproductive Technology

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 15,000 (estimated)
• Sponsor: Women's Hospital School Of Medicine Zhejiang University · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The primary purpose of the study is to investigate the relationship between different protocols of assisted reproductive technology and the epigenetic safety of the offspring. Different interventions of assisted reproductive technology include controlled ovarian hyperstimulation (COH), in vitro embryo culture, in vitro fertilization(IVF), intracytoplasmic sperm injection(ICSI), frozen-thawed embryo transfer(FET), preimplantation genetic testing(PGT). The investigators are also interested in the relationship between pregnancy outcomes in ART or natural conception and environmental, nutritional and lifestyle factors.

Conditions

• Infertility

Interventions

Type	Name	Description
OTHER	Completion questionnaires/providing biological samples	Participant completes baseline interview at enrollment, then completes questionnaires and provides biological samples at each scheduled study visit.

Timeline

• Start date: 2019-09-15
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2019-08-22
• Last updated: 2019-08-22

Locations

1 site across 1 country: China