NCT04064203

The Effect of Insulin-induced Hypoglycaemia on Gut-derived Glucagon Secretion (Px-Hypo)

The Effect of Insulin-induced Hypoglycaemia on Gut-derived Glucagon Secretion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The overall objective of this study is to investigate whether hypoglycaemia (the most potent stimulus of pancreatic glucagon secretion) affects the secretion of gut-derived glucagon in totally pancreatectomized patients.

Detailed description

The investigators want to assess the plasma glucagon response to insulin-induced hypoglycaemia in totally pancreatectomised patients and at the same time evaluate whether hypoglycaemia affects a range of other products from endocrine cells in the gastrointestinal tract including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic polypeptide (GIP), GLP-1, glucagon-like peptide-2 (GLP-2), oxyntomodulin and peptide YY (PYY). Furthermore the investigators will evaluate how hypoglycaemia in these patients affects other counter-regulatory mechanisms including plasma responses of the hormones adrenaline, noradrenaline, growth hormone and cortisol as well as the rate of gastric emptying rate (which under normal circumstances accelerates during hypoglycaemia) during an oral glucose tolerance test (OGTT).

Conditions

• Diabetes After Total Pancreatectomy

Interventions

Type	Name	Description
OTHER	Oral glucose tolerance test	50 grams OGTT
OTHER	Clamp experiment	insulin-induced hypoglycaemic clamp followed by an 50 grams OGTT

Timeline

• Start date: 2017-07-05
• Primary completion: 2018-09-20
• Completion: 2018-09-20
• First posted: 2019-08-21
• Last updated: 2019-08-21

Locations

1 site across 1 country: Denmark