NCT04062786

Postoperative Renal Failure in Cardiac Surgery PMSF-PVC Gradient Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 130 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Acute renal failure is a frequent and severe postoperative complication of cardiac surgery performed under extracorporeal circulation. It is an independent risk factor for mortality and significantly increases the length of hospital stay. The origin of renal insufficiency after extracorporeal circulation is multifactorial (long duration of extracorporeal circulation, hemodynamic instability per and post-extracorporeal circulation, prolonged hypotension, transfusion ...). Nevertheless, an entirely different pathophysiological mechanism, though not recent, is less often mentioned but shows renewed interest. This is the concept of renal venous congestion which may be responsible for impaired renal function in the absence of cardiac dysfunction. Based on Guyton's circulatory model, the investigators approach this systemic venous hypertension through the measurement of the Pmsf-PVC gradient.

Conditions

• Scheduled Heart Surgery
• Valve Replacement
• Coronary Artery Bypass

Interventions

Type	Name	Description
OTHER	Pmsf-PVC gradient measurement	implementation of standard standard hemodynamic monitorin

Timeline

• Start date: 2019-02-21
• Primary completion: 2019-02-21
• Completion: 2020-02-01
• First posted: 2019-08-20
• Last updated: 2019-08-20

Locations

1 site across 1 country: France