Trials / Completed
CompletedNCT04058327
A Study of MHE in Patients With Liver Diseases
A Study on Early Diagnosis and Treatments of Minimal Hepatic Encephalopathy(MHE) in Patients With Liver Diseases
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 252 (actual)
- Sponsor
- Qin Ning · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on chronic liver failure.
Detailed description
Hepatic encephalopathy (HE) is a common complication and one of the most serious manifestations of cirrhosis and acute on chronic liver failure, not only increasing the risks of death, but also seriously affecting the lives of the patients and their caregivers. Minimal hepatic encephalopathy (MHE), the earliest stage of HE, despite its undiscernible clinical evidence, it is related with abnormalities of patients' daily cognition, emotion, muscular strength, driving ability, quality of life and socioeconomic status At present. However, MHE is not easy to diagnose in daily clinical work because of time-consuming psychometric tests, especially the inconvenience of application in weak inpatients. This study aims to analyze the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predict risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on chronic liver failure.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | neurophysiological tests, blood biomarkers. | Let the patients do neuropsychological tests and detect blood biomarkers. |
Timeline
- Start date
- 2019-05-01
- Primary completion
- 2022-12-30
- Completion
- 2022-12-30
- First posted
- 2019-08-15
- Last updated
- 2024-06-17
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04058327. Inclusion in this directory is not an endorsement.