NCT04057508

Non-invasive Modulation of Autonomic Cardiac Nervous System

Effects of Non Invasive Vagus Nerve Stimulation on Heart Rate Variability in Healthy Subjects and on Muscle Sympathetic Nerve Activity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.

Detailed description

First part: Assessment of the muscle sympathetic nerve activity (MSNA) at baseline using microneurography performed on the superficial peroneal nerve. Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration. Continuous recording of the following parameters: * non-invasive arterial blood pressure * R-R interval * electrocardiogram * MSNA activity * respiratory curve signal * respiratory rate, oxygen saturation

Conditions

• Autonomic Nervous System
• Heart Rate Variability
• Muscle Sympathetic Nerve Activity

Interventions

Type	Name	Description
OTHER	Modulation of muscle sympathetic nerve activity	Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation.

Timeline

• Start date: 2019-06-19
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2019-08-15
• Last updated: 2019-08-15

Locations

1 site across 1 country: Belgium