NCT04056676

Analgesic Effect of Adding Thoracic Paravertebral Nerve Blocks to Modified PEC Block in Breast Cancer Surgery

Analgesic Effect of Adding Thoracic Paravertebral Nerve Blocks to Modified PEC Block in Breast Cancer Surgery, Prospective Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To compare efficacy and safety of adding thoracic paravertebral nerve blocks to modified PEC block versus modified PEC block only in breast cancer surgery. This study evaluate systemic opioid requirement in 48 hours in primary outcome and the analgesic profile ( pain score at rest and on shoulder movement), opioid-related side effects and nerve blocks complications.

Detailed description

Regional anesthesia has been used and studied extensively in breast surgery as an opioid-sparing strategy, with block of the intercostal supply by thoracic paravertebral block (TPVB) becoming a popular technique. This prospective randomized controlled trial is aimed to study the proper regional nerve block technique to reach the postoperative opioid-free requirement modality for breast cancer surgery.

Conditions

• Breast Cancer Female
• Pain, Postoperative

Interventions

Type	Name	Description
PROCEDURE	Thoracic paravertebral block under ultrasound guidance	Ultrasound-guided thoracic paravertebral blocks in T2, T4 level
PROCEDURE	Intraoperative modified PEC block	Pectoral nerve block by surgeon under direct vision after total mastectomy
PROCEDURE	GA with ETT	General anesthesia with endotracheal intubation

Timeline

• Start date: 2019-08-01
• Primary completion: 2021-12-01
• Completion: 2022-03-01
• First posted: 2019-08-14
• Last updated: 2021-05-24

Locations

1 site across 1 country: Thailand