NCT04056338

Gut Microbiome and ICU Delirium Post Cardiac Surgeries

Gut Microbiome and Gut Barrier Function in ICU Delirium Post Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

ICU delirium are assessed by clinical nurses twice every day. Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.

Detailed description

ICU delirium are assessed by clinical nurses twice every day using Confusion Assessment Method for the ICU (CAM-ICU). Delirious patients are matched with patients according to their disease, gender and age range(±3 years). Stool samples for gene sequencing are collected within 24 hours after surgeries. Gut barrier function are studied with several serum biomarkers (endotoxin, etc.). Ecological analyses, regression models and mediation equation will be performed.

Conditions

• Intensive Care Unit Delirium

Interventions

Type	Name	Description
OTHER	No intervention	No intervention.

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-12-30
• Completion: 2019-12-30
• First posted: 2019-08-14
• Last updated: 2021-01-29

Locations

1 site across 1 country: China