NCT04056169

Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Yuhan Corporation · Industry
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

Combination therapy of ezetimibe with a low-dose statin is occasionally used to avoid statin-related side effects in clinical practice among patients with atherosclerotic cardiovascular disease. This approach is equivalent to high-dose statin therapy to decrease LDL cholesterol level by \>50%, allowing such patients to achieve LDL cholesterol target. However, it remains uncertain whether combination therapy with ezetimibe and low-dose statin verse high-dose statin monotherapy similarily suppress atherosclerotic plaque inflammation. This study is to compare high-dose rosuvastatin versus low-dose rosuvastatin plus ezetimibe on carotid plaque inflammation in patients with acute coronary syndrome using 18F-fluorodeoxyglucose (18FDG) positron emission tomography (PET) imaging.

Conditions

• Acute Coronary Syndrome
• Carotid Atherosclerotic Plaque With Inflammation

Interventions

Type	Name	Description
DRUG	high-dose rosuvastatin	rosuvastatin 20 mg once a day for 6 months
DRUG	low-dose rosuvastatin plus ezetimibe	ezetimibe/rosuvastatin 10/5 mg once a day for 6 months

Timeline

• Start date: 2017-06-29
• Primary completion: 2019-07-23
• Completion: 2019-07-23
• First posted: 2019-08-14
• Last updated: 2019-08-16

Locations

2 sites across 1 country: South Korea