NCT04053855

Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.

Detailed description

The primary objective is to detect urinary exosomes, by electron microscopy technique, from clear cell renal cell carcinoma due to exosome markers (CD9) and clear cell kidney cancer (CA9).

Conditions

• Clear Cell Renal Cell Carcinoma

Interventions

Type	Name	Description
BIOLOGICAL	Urinary sample	Urinary sample (100 ml) will be collected in the urology department to analysis urinary exosomes.

Timeline

• Start date: 2020-01-29
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2019-08-13
• Last updated: 2024-10-26

Locations

1 site across 1 country: France