NCT04051879

Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 78 (estimated)
• Sponsor: University of California, San Diego · Academic / Other
• Sex: Female
• Age: 13 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The proposed study of adolescents with anorexia nervosa (AN) will examine the association of behavioral differences in constructs of decision making, brain structure and connectivity, and eating disorder (ED) symptoms. This study tests the novel hypothesis that goal-directed and habit learning for reward and punishment is altered in AN and is uniquely associated with divergent symptoms and differences in corticostriatal connectivity and microstructural integrity. We will recruit 78 females currently ill with AN and 26 controls ages 13-17 to investigate how goal-directed and habit learning for reward and punishment correspond to 1) clinical symptoms collected via interviews, self-report assessments, and ecological momentary assessment (EMA), and 2) brain structure and connectivity in the resting state. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Conditions

• Anorexia Nervosa

Timeline

• Start date: 2019-04-01
• Primary completion: 2025-03-24
• Completion: 2027-04-01
• First posted: 2019-08-09
• Last updated: 2025-03-27

Locations

1 site across 1 country: United States