NCT04049851

Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients

Randomized Clinical Trial, Double-blind, Single-dose Drug and Escalating Infection Intensities, Evaluating the Safety and Efficacy of Moxidectin 2 mg, Ivermectin-controlled, in Loa Loa Microfilaremic Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Center for Research on Filariasis and Other Tropical Diseases, Cameroon · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims at evaluating the safety and efficacy of Moxidectin 2 mg in patients with low intensities of microfilariae of Loa loa.

Detailed description

This clinical trial will be randomized, double blind, and will compare Moxidectin to ivermectin. This study will be conducted in Cameroon.

Conditions

• Onchocerciasis, Ocular
• Loiasis

Interventions

Type	Name	Description
DRUG	Moxidectin 2 MG Oral Tablet	One Moxidectin 2 mg tablet will be blinded and will be administrated with 3 tablets of placebo.
DRUG	Ivermectin 3Mg Tab	3 ivermectin tablets (or 4 according to the weight) will be blinded and will be administrated with 1 (or 0 according to the weight) tablet of placebo.
DRUG	Placebo oral tablet	Placebo will be administrated with Moxidectin or ivermectin. Each participant will have 4 tablets in total.

Timeline

• Start date: 2022-04-07
• Primary completion: 2023-07-22
• Completion: 2023-07-22
• First posted: 2019-08-08
• Last updated: 2025-02-24

Locations

1 site across 1 country: Cameroon