NCT04047498

Alternating DBS for Stepping Control in Parkinson's Disease

Studying Stepping Control in Parkinson's Disease Using Alternating DBS

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Parkinson's disease (PD) is a disabling, progressive condition characterised by severe problems with movement for which medical treatment in the longer term can be unsatisfactory. Deep brain stimulation (DBS) is a treatment, which directly stimulates the nerve cells affected inside the brain to help overcome the difficulties with movement. Classically, DBS stimulates in a manner that is constant. Many patients develop severe problems with walking, so-called freezing of gait, which can be unresponsive to constant DBS. In this study the investigators will test if left-right alternating DBS helps to improve gait problems by potentially promoting left-right alternating up- and down-modulated brain activity, which was found during walking in a previous study. The investigators will test if alternating DBS improves the ability to adjust walking speed and to walk freely compared to constant DBS.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
DEVICE	Alternating DBS	Constant DBS will be changed to DBS that is up- and downmodulated alternating between the left and right stimulation side.

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-09-01
• Completion: 2020-11-01
• First posted: 2019-08-06
• Last updated: 2019-08-06

Locations

2 sites across 1 country: United Kingdom

Regulatory

• FDA-regulated device study