NCT04046731

Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation

The Negative Predictive Value and Non-irritant Skin Testing Concentrations of Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 187 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.

Detailed description

This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs. It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).

Conditions

• Allergy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Skin Testing	Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control.

Timeline

• Start date: 2019-09-20
• Primary completion: 2021-12-30
• Completion: 2021-12-31
• First posted: 2019-08-06
• Last updated: 2022-02-02

Locations

1 site across 1 country: United States