NCT04046003

Tai Chi for Knee OA Pain Management: a Mechanistic Study

Tai Chi for Pain Management of Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Texas Tech University Health Sciences Center · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA.

Detailed description

Knee osteoarthritis (OA) is one of the five leading causes of disability. Previous studies have shown that a mind-body moderate-intensity Tai Chi (TC) exercise (8-24 weeks) reduced pain and improved physical function for knee OA, when compared to a waiting list, attention control, usual physical activity, or physical therapy. However, TC's mechanisms of action regarding improvement of one's clinical condition and its functional outcomes in individuals with knee OA are poorly understood. This study is to determine how 8-week TC intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA.

Conditions

• Knee Osteoarthritis
• Mind-body Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Tai chi exercise	24-form Yang style Tai Chi (60 min/session, 3 sessions/week) for 8 weeks

Timeline

• Start date: 2019-09-01
• Primary completion: 2024-06-30
• Completion: 2024-08-31
• First posted: 2019-08-06
• Last updated: 2025-03-28

Locations

1 site across 1 country: United States