NCT04043026

The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function

Stratifying Clinical Risk in Patients With Atrial Fibrillation and Chronic Kidney Disease by Studying How Abnormalities in Clot Structure/Function and Lipoproteins Contribute to Thrombosis and Bleeding

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 56 (actual)
• Sponsor: University of Liverpool · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to investigate the role of lipids/lipoproteins as a potential cause for the harmful changes seen in fibrin clot properties with renal dysfunction and atrial fibrillation

Detailed description

This is a prospective, observational, blinded study that will be conducted in two parts. The first study will assess the relationship between lipids/lipoproteins and fibrin clot properties among anticoagulated atrial fibrillation patients with and without renal dysfunction. The second study will assess the effects of statin therapy on lipids/lipoproteins and fibrin clot properties in anticoagulated atrial fibrillation patients with renal dysfunction. Renal dysfunction is defined as an estimated glomerular filtration rate below 50 ml/min/1.73m2 for the purposes for this trial.

Conditions

• Atrial Fibrillation
• Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	Statin	Any statin therapy

Timeline

• Start date: 2019-09-26
• Primary completion: 2022-08-01
• Completion: 2022-08-01
• First posted: 2019-08-02
• Last updated: 2022-08-08

Locations

2 sites across 1 country: United Kingdom