NCT04041024

Decision-making and Risk-taking in Bulimia

Identification of Decision Making Processes in Food, Risky and Steal Situations in Bulimia Nervosa

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: Hôpital le Vinatier · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This trial is a set of four independent experiments involving for each of them functional and structural MRI data acquisition. They aim at investigating decision making mechanisms in bulimia nervosa when participants have to make food or monetary choices under specific conditions that mimic binge eating episodes or kleptomania which are two major symptoms of bulimia nervosa. All experiments are cross sectional studies. Each experiment is subdivided into two parts: a first part without any MRI data acquisition and during which all the tasks are performed. This part aims at making sure that a behavioral effect is observed before starting MRI data acquisition. The second part aims at investigating the neural correlates observed in the first part and additionally, at reproducing the behavioral effects observed in the first part. Therefore the first part may be regarded as an independent study as compared to the second part.

Detailed description

Each part of each experiment is built of a main task, a set of secondary tasks and questionnaires. Only the main task changes from one experiment to another. Within each experiment, the only difference between the two parts is that the main task is performed while participants are being scanned in an MRI scanner. Details of the tasks are provided below. Each part of each experiment is performed over one visit only and is a cross sectional study. The visit is dedicated to the tasks. Questionnaires may be filled during the visit or at participant's home within the week following the visit for questionnaires which are not assessing participant's state. Questionnaires assessing participant's state are filled during the visit at appropriate time. The total number of participants mentioned below is the sum of the planned number of participants within each group, i.e. patients and healthy participants, within each part of each experiment.

Conditions

• Bulimia Nervosa

Interventions

Type	Name	Description
OTHER	tasks and questionnaires	Each of the 4 experiments is built of a main task. The first task involves a first phase of subjective valuation of food items. The second phase requires from the participant to make a choice between two out of three food items selected by the computer.
OTHER	tasks and questionnaires	Each of the 4 experiments is built of a main task. The first task involves a first phase of subjective valuation of food items. The second phase requires from the participant to make a choice between two out of three food items selected by the computer.

Timeline

• Start date: 2020-10-28
• Primary completion: 2021-06-15
• Completion: 2021-06-15
• First posted: 2019-08-01
• Last updated: 2021-09-16

Locations

1 site across 1 country: France