NCT04036097

Prospective Stratification of Infectious Risks in Multiple Sclerosis

Prospective Stratification of Infectious Risks in Multiple Sclerosis (InRIMS-Study)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 298 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This monocentric study is to identify factors that increase the susceptibility for infections and establish a questionnaire-based infection score that allows a prospective stratification for infectious risks in patients with multiple sclerosis (MS) (InRIMS-Study). The study will utilize a validated, MS-adapted questionnaire and infection diary from the Airway Infection Susceptibility (AWIS) study in a regularly followed, prospective cohort of MS patients. It is a nested project of the prospective observational Swiss MS Cohort (SMSC) and SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation) studies.

Conditions

• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	MS-adapted AWIS questionnaire (MS-AWIS)	The predefined questionnaire-based infection score of the Airway Infection Susceptibility (AWIS) study is predictive for the occurrence of respiratory tract infections (RTI). In addition several MS-specific items (e.g. bladder dysfunction and urinary tract infections) are included into the AWIS questionnaire (MS-AWIS).
OTHER	infection diary (MS-AWIS diary)	MS patients prospectively fill out monthly infection diaries for 24 months. Infection diaries will either be sent back (with pre-franked envelopes) or handed back to the InRIMS-study team during regular clinical visits (usually every 6 or 12 months).

Timeline

• Start date: 2019-04-10
• Primary completion: 2022-12-31
• Completion: 2023-12-31
• First posted: 2019-07-29
• Last updated: 2025-04-17

Locations

1 site across 1 country: Switzerland