NCT04035707

Serum Tryptase Concentration During General Anaesthesia With Rocuronium

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: Medical University of Bialystok · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Rocuronium is a aminosteroid structured, non-depolarizing neuromuscular blocking agents (NMB). Epidemiological data presents that the frequency of hypersensitivity reactions caused by rocuronium have been increased. Determinations of serum tryptase concentrations are interdisciplinary recommended in diagnosis of its adverse reactions. No studies have been performed to explain specific role of rocuronium doses on serum tryptase values. The aim of this study was to investigate the potential effect of rocuronium on serum tryptase concentrations.

Detailed description

The greatest risk of hypersensitivity occurs during anesthesia for female patients and it is connected with the induction phase using skeletal muscle relaxants . Epidemiological data presents that the frequency of hypersensitivity reactions caused by rocuronium have been increased. Due to the multiple advantages reports of triggering allergic or hypersensitivity reactions caused by rocuronium create doubts about the safety of application .

Conditions

• Hypersensitivity Reaction

Interventions

Type	Name	Description
DRUG	Rocuronium	using rocuronium as a relaxants during general anaesthesia
DRUG	general volatile anaesthesia	method of anaesthesia

Timeline

• Start date: 2009-06-25
• Primary completion: 2010-06-25
• Completion: 2014-05-15
• First posted: 2019-07-29
• Last updated: 2019-07-29