NCT04027465

Egg Allergy Oral Desensitization

Egg Desensitization and Induction of Tolerance in Children

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre · Academic / Other
• Sex: All
• Age: 6 Years – 20 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates whether tolerance to eggs can be induced in patients through a process of oral immunotherapy. Participants will be randomized into groups receiving oral immunotherapy and a control group that will receive no intervention

Detailed description

The investigators are proposing to initiate a study assessing a common desensitization protocol for egg allergy. This study would enable the investigators to better determine the potential benefit of desensitization in individuals with egg allergy. More specifically, the investigators will address the following research objectives: Objectives A. To develop a protocols for egg desensitization B. To determine the rate of desensitization to egg. C. To characterize predictors of successful desensitization. D. To characterize molecular mechanisms involved in the process of desensitization These objectives will be evaluated through a randomized controlled trial

Conditions

• Egg Protein Allergy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Egg allergy oral desensitization	Subjects in the treatment will begin treatment by undergoing an egg oral challenge. This will confirm that the subject is still allergic to egg and establish the dose of egg the subject can tolerate. The last dose of egg tolerated during the challenge will serve as the first desensitization dose Subjects will then come to the research center every two weeks to receive their dose increases until they reach the maintenance dose of 300 mg. Subjects will then enter the maintenance phase for one year. During this period they will undergo another oral food challenge one month after attaining the maintenance dose

Timeline

• Start date: 2018-07-03
• Primary completion: 2023-07-02
• Completion: 2023-07-02
• First posted: 2019-07-22
• Last updated: 2022-07-26

Locations

2 sites across 1 country: Canada