NCT04027283

Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism

Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Gastrointestinal Hormone Secretion and Glycemic Control

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone responses, glycemic control, gastric emptying (GE) rates and appetite-related sensations to ig administration of erythritol and D-allulose.

Detailed description

Erythritol (natural non-caloric sweetener) could be an ideal candidate substitute for sugar as it may reduce caloric intake without compensatory overeating or earlier return of hunger. Moreover, it may serve as a physiological tool to disentangle the effects of gastrointestinal (GI) sweet taste receptor stimulation, (an)orexigenic hormone secretion, and glucose metabolism/caloric content on food intake regulation in vivo in humans. However, its effects on appetite, satiation, and satiety have not been studied systematically. Moreover, the mechanisms underlying erythritol-induced anorexigenic GI hormone release have not been investigated so far. D-allulose is a sugar substitute with almost zero calories and is naturally occurring in small quantities. Apart from its use as sugar replacement, D-allulose seems to favorably affect glycemic control and metabolism as could be shown in animal trials and in a few human trials. However, to date the effects of D-allulose on GI hormone secretion, appetite-related sensations and glycemic control, are not or insufficiently studied in humans. The aim of this project is therefore to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone responses, glycemic control, gastric emptying (GE) rates and appetite-related sensations to ig administration of erythritol and D-allulose.

Conditions

• Physiological Satiation Mechanisms

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Erythritol	50g erythritol dissolved in 300mL tap water
DIETARY_SUPPLEMENT	Erythritol + lactisole	50g erythritol + lactisole (450ppm) dissolved in 300mL tap water
DIETARY_SUPPLEMENT	D-allulose	25g D-allulose dissolved in 300mL tap water
DIETARY_SUPPLEMENT	D-allulose + lactisole	25g D-allulose + lactisole (450ppm) dissolved in 300mL tap water
DIETARY_SUPPLEMENT	Tap water	300mL tap water
DIETARY_SUPPLEMENT	Tap water + lactisole	300mL tap water + lactisole (450ppm)

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-09-01
• Completion: 2020-09-01
• First posted: 2019-07-19
• Last updated: 2020-09-29

Locations

1 site across 1 country: Switzerland