NCT04025138

Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory. The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that: * A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that, * Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race. According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.

Detailed description

Thus, the main purpose of the present project is to investigate whether sex differences in neuromuscular fatigue in plantar flexors depend on the distance (\> 100 km vs \< 60 km).

Conditions

• Ultra-marathon Runners

Interventions

Type	Name	Description
OTHER	Neuromuscular tests in isometric mode	Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures : * Voluntary maximum forces plantar flexors and knee extensors * Electrically evoked forces * ElectroMyoGraphic activity (EMG) * Three-Modality Evoked Potentials (TMEPs)
DEVICE	Transcranial Magnetic Stimulation (TMS)	Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).
OTHER	Neuromuscular fatigue assessment test	Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.
OTHER	treadmill	2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.
BIOLOGICAL	Blood sample	Blood sample will be realized to measure hemorrheologic and hematologic parameters.
BIOLOGICAL	Urinary sample	Urinary sample will be realized to measure hemorrheologic and hematologic parameters.

Timeline

• Start date: 2019-07-02
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2019-07-18
• Last updated: 2022-12-15

Locations

1 site across 1 country: France