NCT04024631

Phenotyping Genetic Risk for Type 2 Diabetes

Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 10 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Detailed description

The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will undergo a frequently sampled four-hour oral glucose tolerance test and whole body DXA scan (dual-energy X-ray absorptiometry) in addition to baseline laboratory and history assessment.

Conditions

• Diabetes Mellitus, Type 2
• Genetics

Interventions

Type	Name	Description
OTHER	75g glucose beverage (Glucola, Trutol, or similar brand)	Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.
OTHER	DXA, whole body	Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.

Timeline

• Start date: 2019-06-17
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2019-07-18
• Last updated: 2025-09-10

Locations

2 sites across 1 country: United States