NCT04024527

High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori RescueTreatment

Efficacy of High Dose of Dual Therapy Plus Metronidazole for Helicobacter Pylori Rescue Treatment: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 306 (actual)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Dual therapy containing high dose of proton pump inhibitor (PPI) and amoxicillin had showed excellent eradication results with Helicobacter pylori first-line treatment. However, no study has examined the the efficacy of high dose of dual therapy or dual therapy plus metronidazole for H. pylori rescue treatment.This study is designed to evaluate the efficacy and safety of the addition of metronidazole to high dose of dual therapy for H. pylori rescue treatment.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Esomeprazole	Proton pump inhibitor
DRUG	Amoxicillin	Antibiotic for H. pylori eradication
DRUG	Metronidazole	Antibiotic for H. pylori eradication

Timeline

• Start date: 2019-07-25
• Primary completion: 2021-04-12
• Completion: 2021-05-24
• First posted: 2019-07-18
• Last updated: 2021-09-28

Locations

1 site across 1 country: China