NCT04024020

Chronic Insomnia and CSF Markers of Dementia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: —

Summary

The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years.The purpose of this study is to examine the relationship between chronic insomnia and dementia biomarkers and orexin levels found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia and age- and gender-matched good sleepers will undergo overnight polysomnography and CSF sampling in the morning.

Conditions

• Insomnia Chronic

Interventions

Type	Name	Description
OTHER	lumbar puncture	Subjects will have a lumbar puncture to collect cerebrospinal fluid collection

Timeline

• Start date: 2019-01-01
• Primary completion: 2023-10-31
• Completion: 2023-10-31
• First posted: 2019-07-18
• Last updated: 2025-01-23
• Results posted: 2025-01-23

Locations

1 site across 1 country: United States