NCT04020146

PPAR, RXR, and VDR Expressions in Peri-implantitis

PPAR-γ, RXR, and VDR Expressions in Gingival Tissue Samples of Healthy Individuals, Periodontitis and Peri-implantitis Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Tokat Gaziosmanpasa University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

ABSTRACT Objective: Periodontitis and peri-implantitis are the irreversible destructive diseases of the periodontal and peri-implant tissues. The present study aimed to determine the receptor expressions of Peroxisome proliferative-activated receptor (PPAR)-γ, Retinoid X receptor (RXR)-α, and Vitamin D receptor (VDR) in the diseased tissues around teeth and dental implants. Methods: The study consisted of three groups as group 1; healthy controls (C, n=15), group 2; periodontitis patients with stage 3 grade B (P, n=15), and group 3; peri-implantitis patients (PI, n=15). Periodontal clinical parameters as the plaque index (PI), gingival index (GI) and clinical attachment levels (CAL) were recorded. Gingival biopsies were obtained from all participants and biopsy samples underwent histological tissue processing. Hematoxylin-eosin (H\&E) and immunohistochemistry staining were performed. Total inflammatory cell counts and fibroblast cell density were evaluated on H\&E-stained slides while PPAR-γ, RXR-α, and VDR were evaluated via immunohistochemistry.

Conditions

• Periodontitis
• Periimplantitis

Interventions

Type	Name	Description
OTHER	Gingival biopsies	Gingival biopsies were obtained from all participants and biopsy samples underwent histological tissue processing.

Timeline

• Start date: 2018-01-10
• Primary completion: 2019-01-10
• Completion: 2019-03-10
• First posted: 2019-07-15
• Last updated: 2019-07-15

Locations

1 site across 1 country: Turkey (Türkiye)