NCT04019951

The Effect of a Propionate Colon Release Form on ad Libitum Eating and Appetite Perception

The Effect of a Standardized Liquid Breakfast Containing a Propionate Colon Release Form on ad Libitum Eating and Appetite Perception in Healthy Overweight Humans: A Double-blinded, Randomized, Cross-over Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: dsm-firmenich Switzerland AG · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The present study aims to investigate the effect of a standardized liquid breakfast containing a food grade propionate colon release form on ad libitum eating and appetite perception in healthy overweight humans using a double-blinded, randomized, cross-over study design

Detailed description

To determine, in healthy overweight subjects, the acute effect of a standardized liquid breakfast containing a propionate colon release form compared with placebo on appetite and GI comfort, food intake, serum glucose and insulin, plasma ghrelin, total GLP-1 and serum PYY concentrations, and plasma propionate concentrations

Conditions

• Overweight

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ca-propionate 1 g	1 g of Ca-propionate will be mixed in 203 mL of a standardized liquid breakfast
DIETARY_SUPPLEMENT	Ca-propionate 3 g	3 g of Ca-propionate will be mixed in 203 mL of a standardized liquid breakfast
DIETARY_SUPPLEMENT	Placebo	2.6 g of cellulose will be mixed in 203 mL of a standardized liquid breakfast

Timeline

• Start date: 2019-01-01
• Primary completion: 2019-10-01
• Completion: 2020-02-01
• First posted: 2019-07-15
• Last updated: 2020-03-30

Locations

1 site across 1 country: Canada