NCT04019509

The Influence of Different Thyroid Autoantibodies on Thyroid Function and Pregnancy Outcome After Assisted Reproductive Technology

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 900 (estimated)
• Sponsor: Universitair Ziekenhuis Brussel · Academic / Other
• Sex: Female
• Age: 18 Years – 36 Years
• Healthy volunteers: Accepted

Summary

The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known. The objectives of the present study are: 1. To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies. 2. Compare pregnancy outcome between women with and without thyroid antibodies

Detailed description

Thyroid autoantibodies and / or abnormal thyroid function are associated with fertility problems. A possible explanation for this is, an influence of thyroid autoantibodies on the functioning of the thyroid gland. It is therefore recommended to check thyroid gland function and for the presence of autoantibodies before pregnancy. In general, 2 types of thyroid autoantibodies are known: anti-thyreoperoxidase autoantibodies and anti-thyroglobulin autoantibodies. In case of abnormal thyroid function, treatment is sometimes necessary in regards to fertility. The risk of abnormal thyroid function is increased in women with thyroid autoantibodies during pregnancy. Therefore, thyroid function is regularly monitored during pregnancy in women with thyroid antibodies. The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known. The objectives of the present study are: 1. To monitor the course of thyroid function during pregnancy and to compare between women with and without thyroid autoantibodies. 2. Compare pregnancy outcome between women with and without thyroid antibodies

Conditions

• Fertility Disorders
• Thyroid Dysfunction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	blood test	blood test for thyroid antibodies and thyroid function (TSH, FT4)
OTHER	follow up treatment outcome	questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery

Timeline

• Start date: 2019-01-01
• Primary completion: 2022-01-01
• Completion: 2022-09-01
• First posted: 2019-07-15
• Last updated: 2019-07-15

Locations

1 site across 1 country: Belgium